It was defined for the first time by the French scientist Dr. Michel Pistor in 1952, and it was approved by the FNAM organization for its applications in the cosmetic field in 1986. Mesotherapy is listed among minimally invasive methods. It aims to eliminate many negative effects on the skin with small touches. The procedure can be performed not only by the micro-needling method but also by injection of minerals, amino acid complex, and vitamins under the skin during needling. It can be used for skin spot treatment, rejuvenation, scar treatment and hair rejuvenation. Recently, it has been used both in weight loss and in the treatment of stretch marks and cellulite. Treatment takes up to 15 minutes. The interval between sessions is about 3 weeks.